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Friemert, C. ; Closs, E.I. ; Silbermann, M.H. ; Erfle, V.F. ; Strauß, P.G.

Isolation of a cathepsin B-encoding cDNA from murine osteogenic cells.

Gene 103, 259-261 (1991)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cathepsin B-encoding cDNA (CTSB) clones have been isolated from a λgt10 library of a murine osteosarcoma by differential screening during a search for genes which are typically expressed during osteogenic differentiation in mouse mandibular condyles in vitro. Sequencing of the CTSB 3' end revealed that the isolated sequence contained an 825-bp 3'-noncoding region, the polyadenylation signal and the poly(A) tail. The enhanced CTSB expression during the early stages of the enchondral ossification-like process in mandibular condyles in vitro suggests that CTSB participates in the degradation of cartilage matrix prior to the synthesis of bone matrix proteins.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 3' End ; Cdna Sequence ; Cysteine Proteinase ; Gene Expression ; Mouse Mandibular Condyles ; Osteogenic Differentiation
ISSN (print) / ISBN 0378-1119
e-ISSN 1879-0038
Zeitschrift Gene
Quellenangaben Band: 103, Heft: 2, Seiten: 259-261 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed