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Retrovirus-induced osteopetrosis in mice : Ultrastructural evidence of early virus production in osteoblasts and osteocytes.
Am. J. Pathol. 124, 319-323 (1986)
Newborn female strain NMRI mice were given injections of a mouse retrovirus (OA MuLV) known to induce osteopetrosis, osteoma, and lymphoma. Femur metaphyses and lumbar vertebrae were investigated ultrastructurally 3 d, 7 d and 28 d after infection. Budding, immature and mature virus was observed associated with osteoblasts and osteocytes, but not with osteoclasts or chondrocytes, 28 d after infection with the virus. No production of virus particles was observed in bone-tissue in mock-treated controls. Thus, the primary target cell for OA virus in bone appears to belong to the osteoblastic/osteocytic cell lineage.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0002-9440
e-ISSN
1525-2191
Zeitschrift
American Journal of Pathology, The
Quellenangaben
Band: 124,
Heft: 2,
Seiten: 319-323
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pathology (PATH)