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Cholestyramine enhances fecal elimination of pentachlorophenol in rhesus monkeys.
Chemosphere 10, 877-888 (1981)
The effect of cholestyramine in the daily diet upon the excretion of pentachlorophenol with the feces was studied in the rhesus monkey. The treatment increased fecal elimination of pentachlorophenol and/or metabolites up to 9- to 14-fold over a six-day period. At the same time urinary excretion was reduced 2- to 6-fold. The data suggest that cholestyramine interrupts the enterhepatic circulation of PCP and/or metabolites thus indicating its possible usefulness in preventing toxicity of PCP that otherwise may occur due to reabsorption of biliary PCP and/or metabolites.
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Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
1981
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0045-6535
e-ISSN
1879-1298
Zeitschrift
Chemosphere
Quellenangaben
Band: 10,
Heft: 8,
Seiten: 877-888
Verlag
Elsevier
Verlagsort
Kidlington, Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Ecological Chemistry (IOEC)
Scopus ID
0019822049
Erfassungsdatum
1981-12-31