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Taurolithocholate inhibits taurocholate uptake by isolated hepatocytes at low concentrations.
Naunyn-Schmiedebergs Arch. Pharmakol. 298, 175-179 (1977)
The cholestatic bile acid taurolithocholate inhibits taurocholate uptake by isolated liver cells non-competitively. Inhibition is instantaneous and inversely related to the cell number in the incubate. The Kiamounts to 7 μM in the presence of 2 mg cellular protein per ml. Secretion of taurocholate by isolated liver cells is not affected by taurolithocholate up to a concentration of 50 μM. This indicates a difference between the carrier for taurocholate uptake and the carrier for taurocholate secretion. Inhibition of bile acid uptake by liver cells may be involved in the pathogenesis of lithocholate-induced cholestasis.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cholestasis ; Isolated Hepatocytes ; Taurocholate ; Taurolithocholate ; Transport
ISSN (print) / ISBN
0028-1298
e-ISSN
1432-1912
Zeitschrift
Naunyn-Schmiedeberg's Archives of Pharmacology
Quellenangaben
Band: 298,
Heft: 2,
Seiten: 175-179
Verlag
Springer
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Toxikologie und Biochemie