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The R.B.E. Of fast fission neutrons (2 mev) for chronic radiation damage of the large bowel of rats after single dose and fractionated irradiation.
Int. J. Radiat. Biol. 49, 1031-1038 (1986)
Late damage in the rectum of rats was studied after local irradiation with 2 MeV fast fission neutrons and the results were compared with those for 300 kV X-rays. A similarity between latency times, and between clinical, gross pathological and histological appearances of the rectal obstruction after the two types of radiation was observed. The r.b.e. evaluated from ED 50 200 days values was 1·8 for single doses, 2·1 for two fractions and 3 for five fractions and these are similar to r.b.e.s from other investigations of chronic intestinal radiation damage. Using linear quadratic analysis, a limiting r.b.e. of 5 was obtained. The βvalues are similar for both radiation qualities. Because of the high γcontamination (25 per cent) in the RENT I beam a possible correction of the r.b.e. for neutrons only, assuming interaction, is discussed.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Bowel Stenosis ; Chronic Radiation Damage ; Fractionation ; Neutrons
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Zeitschrift
International Journal of Radiation Biology
Quellenangaben
Band: 49,
Heft: 6,
Seiten: 1031-1038
Verlag
Informa Healthcare
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)