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Marquart, K.H.

Pleomorphic C-type virus particles in bone tissue of strain 101 mice and (C3H × 101)F1 hybrids.

Calcif. Tissue Int. 28, 259-262 (1979)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The proximal tibial metaphysis of apparently healthy strain 101 mice, 3-4 weeks old, and (C3H×101)F1 hybrids, 3-48 weeks old, was studied by electron microscopy. Budding, immature, and mature C-type virus particles were found within trabecular bone tissue of 3 of 8 strain 101 and 4 of 12 (C3H×101)F1 mice. The particles were most common in lacunae of aging osteocytes and were only occasionally associated with osteoblasts. Although the morphology of budding and immature particles appeared to be identical with that of typical C-type viruses, most of the mature forms of particles showed atypical structure and size. The electron-dense core was very large and not clearly defined, measuring approximately 70-130 nm in diameter. This diffuse core sometimes completely filled the space within the envelope of the particles. The diameters of the pleomorphic mature C-type particles ranged from approximately 90 to 150 nm. The possible association between the production of pleomorphic C-type virus particles by bone cells and spontaneous osteomagenesis in 101 and (C3H × 101)F1 mice is discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bone Tissue ; C-type Virus Particles ; Mice
ISSN (print) / ISBN 0171-967X
e-ISSN 1432-0827
Zeitschrift Calcified Tissue International
Quellenangaben Band: 28, Heft: 1, Seiten: 259-262 Artikelnummer: , Supplement: ,
Verlag Springer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)