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Time and dose dependency of bone-sarcomas in patients injected with radium-224.
Radiat. Environ. Biophys. 27, 103-114 (1988)
The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity.
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Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
1988
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Zeitschrift
Radiation and Environmental Biophysics
Quellenangaben
Band: 27,
Heft: 2,
Seiten: 103-114
Verlag
Springer
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)
PubMed ID
3164868
Scopus ID
0023919148
Erfassungsdatum
1988-12-30