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Lau, B. ; Jäger, G. ; Thiel, E.V. ; Pachmann, K. ; Rodt, H.V. ; Huhn, D. ; Thierfelder, S.S. ; Dörmér, P.G.

Phenotypic changes in acute lymphoblastic leukemia cells of the common type in diffusion chambers.

Leuk. Res. 4, 561-569 (1980)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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cALL positive blast cells from peripheral blood of four children as well as cells from the Reh line were cultivated in DC in order to promote cell differentiation. DC were implanted into the peritoneal cavity of pre-irradiated CBA mice. At different intervals during the culture period changes in the membrane marker profile were determined by direct immunofluorescence after labeling the cells with AcALLG, ATCG and polyvalent AIg. In addition, the ability of cells to form rosettes with SRBC, AET-treated sheep erythrocytes and mouse red blood cells was tested. In the course of the culture the majority of cALL positive cells from three patients (T.H., V.M., I.G.) simultaneously developed a positive reaction with polyvalent AIg. Furthermore, a remarkable portion of cells in V.M. turned out to become positive with only AIg. Comparable results together with an increasing percentage of M-RFC were obtained in the fourth patient, C.M., using AIg(Fab)2. Besides this development, quite a few cells expressing the T-cell antigen occurred in the latter two patients. In the case of the Reh line, the cells developed T-cell antigen, and in one of two experiments they further acquired an E-receptor. Conversely, in the second experiment a receptor for mouse red blood cells was detected. Our data suggest that malignant cells carrying the cALLA are representative of an early developmental stage of lymphatic ontogeny.

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