PuSH - Publikationsserver des Helmholtz Zentrums München: Distribution and bioconcentration potential of the environmental chemical pentachlorophenol (PCP) in different tissues of humans.

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Geyer, H.J. ; Scheunert, I. ; Korte, F.

Distribution and bioconcentration potential of the environmental chemical pentachlorophenol (PCP) in different tissues of humans.

Chemosphere 16, 887-899 (1987)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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The bioconcentration factors (BCFs) of pentachlorophenol (PCP) in different tissues, organs and body fluids of humans were calculated by two methods: 1) from daily intake of PCP and its measured concentrations in different tissues and, 2) from measured half-life and measured PCP concentrations in the human body at steady state using a linear one compartment pharmacokinetic model. The BCFs (based on wet weight) in liver, brain, blood, spleen and adipose tissue of humans as calculated by method 1 were 5.7, 3.3, 1.4, 1.4, and 1.0, respectively. The figures obtained by method 2 were in good agreement to those obtained by method 1.

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