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Frankenberg-Schwager, M. ; Frankenberg, D. ; Bloecher, D. ; Adamczyk, C.

Effect of dose rate on the induction of DNA double-strand breaks in eukaryotic cells.

Radiat. Res. 87, 710-717 (1981)
Verlagsversion DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Irradiation of diploid yeast cells with 30-MeV electrons at a high dose rate (130 Gy/min) was previously shown to yield a linear-quadratic function between irreparable double-strand breaks and dose. The quadratic term is reduced when irradiation is performed with 60Co γ rays at a low dose rate (0.55 Gy/min). This effect of dose rate at the level of double-strand breaks correlates with that previously found at the level of colony-forming ability of yeast cells irradiated in the same dose range. By analogy with the results obtained in survival studies it is proposed that the linear component of the relationship between irreparable double-strand breaks and dose is due to a single track of an electron of medium energy, whereas the quadratic component is caused by the cooperative effect of track ends, each of which is produced by a separate traversal of a slow electron through the yeast nucleus.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0033-7587
e-ISSN 1938-5404
Zeitschrift Radiation Research
Quellenangaben Band: 87, Heft: 3, Seiten: 710-717 Artikelnummer: , Supplement: ,
Verlag Radiation Research Society
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Abteilung Biophysikalische Strahlenforschung