Identification of genetic variants affecting complex traits such as obesity is confounded by many types of bias, especially when effect sizes are small. Given our findings of a positive association between rs7566605 and body mass index in four out of five separate samples, a false positive finding cannot be ruled out with certainty but seems unlikely. Meta-analyses of multiple large studies will help refine the estimate of the effects of rs7566605 on body mass index.
POF Topic(s)30202 - Environmental Health 30205 - Bioengineering and Digital Health 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er)Genetics and Epidemiology Enabling and Novel Technologies