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Rauscher, K.H. ; Bauchinger, M.

Chromosome aberrations induced in patients treated with chemotherapeutic drugs and irradiation for acute lymphatic leukemia.

Hum. Genet. 64, 73-79 (1983)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Chromosome analyses were carried out in lymphocytes of ten children with ALL, prior to and during combined therapy with antineoplastic drugs and cranial irradiation. Chromosome preparations from group I (four patients) were analysed by conventional staining. For group II (six patients) the FPG technique (fluorescence plus Giemsa) was applied after BrdU treatment of cultures and cells were scored exclusively in first division. A significant clastogenic effect could not be detected in samples collected during or after chemotherapy for either group. After cranial irradiation of those patients in group II, linear dose-effect relationships for dicentric plus ring chromosomes, and for excess acentrics, could be demonstrated after correction for the relative amount of irradiated volume.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1983
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0340-6717
e-ISSN 1432-1203
Zeitschrift Human Genetics
Quellenangaben Band: 64, Heft: 1, Seiten: 73-79 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
PubMed ID 6575955
DOI 10.1007/BF00289483
Scopus ID 0020517292
Erfassungsdatum 1983-12-30
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