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Müsch, H.R. ; Bornhausen, M. ; Kriegel, H. ; Greim, H.A.

Methylmercury chloride induces learning deficits in prenatally treated Rats.

Arch. Toxicol. 40, 103-108 (1978)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Methylmercury chloride (MMC) was given to pregnant rats on the 6th, 7th, 8th, and 9th day after conception in doses of 0.05 and 2.0 mg/kg/day. The female offspring of these animals were tested 90 days after birth for learning ability using operant conditioning procedures. The rats were kept at 90% of their normal body weight and trained in a lever-box to press a bar in order to obtain a food pellet. Significant differences in the acquisition speed became apparent when the ratio of bar presses to reward was increased in a classical contingency of differential reinforcement of high rates even at MMC-doses of 4 × 0.05 mg/kg. These differences were not found in the general motility level nor in motor coordination.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Learning ; Methylmercury Chloride ; Operant Behaviour ; Prenatal Treatment ; Rats
ISSN (print) / ISBN 0340-5761
e-ISSN 1432-0738
Zeitschrift Archives of Toxicology
Quellenangaben Band: 40, Heft: 2, Seiten: 103-108 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Radiation Biology (ISB)
Abteilung für Nuklearbiologie