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Dörmér, P.G. ; Lau, B. ; Wilmanns, W.

Kinetics of bone marrow cell production in human acute and chronic myeloid leukemias.

Leuk. Res. 4, 231-237 (1980)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Utilizing a technique of quantitative 14C-autoradiography, relative rates of cell production were determined in the various morphological cell compartments of erythro- and granulo-cytopoiesis in human myeloid leukemias. AML, chronic phase of CML as well as blastic crisis of CML were studied. From the ratios of relative cell production rates in the individual compartments of the white and red cell lineages and by comparison of the two lineages, implications concerning a reduction or increase of cell production are derived. A deficit of erythroblast production increasing with progression towards the more mature stages was attributed to ineffective erythropoiesis. The loss of erythroblasts in the proliferative pool ranged from 45% in CML to 79% in AML. The ratios of granulocytic precursor production in the various CML compartments (chronic phase) were normal. In AML and blastic crisis of CML, on the other hand, an excess of blast cell production was observed. In view of the complete analysis of all proliferative cells in these bone marrows, it appears that there is a capacity of blast cells to expand in number by self-amplification. This self-amplification is not necessarily restricted to one morphological cell type. It takes place among myeloblasts, but promyelocytes may also exhibit this 'leukemic' type of cell growth. The data further suggest that the stem cell influx into the red and presumably also granulocyte series is roughly normal in AML and blastic crisis of CML, whereas it is increased in CML.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Zeitschrift Leukemia Research
Quellenangaben Band: 4, Heft: 21, Seiten: 231-237 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed