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P. Lay, J. ; Klein, W. ; Korte, F.

Elimination- and biodistribution studies of [14C]dodecylbenzene sulfonate in rats, following low dosing in the daily diet and a single i.p. administration.

Toxicol. Lett. 17, 187-192 (1983)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
14C-labelled sodium dodecylbenzene sulfonate (DBS) was administered daily in the diet at a concentration of 1.4 mg/kg to male rats for 5 weeks. From the total uptake (1.213 ± 0.08 mg/animal) of DBS, 81.8% was excreted during the dosing period; 52.4% in feces and 29.4% in urine. Low levels of [14C]DBS-derived residues were detected in all tissues analyzed on day 35 of the experiment. Following 1 week on normal diet only 7.8% of the nominally stored amount of 14C was found in the excreta. Single i.p. application of 0.385 mg [14C]DBS/rat (2.26 ± 0.15 mg/kg body wt.) resulted in a total elimination of 94.5% within 10 days. 84.7% of the dose was eliminated in the first 24 h. All fecal and renal [14C]DBS-derived activity consisted of highly polar metabolites.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Excretion ; Linear Detergent ; Metabolism ; Rats
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Zeitschrift Toxicology Letters
Quellenangaben Band: 17, Heft: 1-2, Seiten: 187-192 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Ecological Chemistry (IOEC)