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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
RBE values for the induction of DNA double strand breaks as a function of photon energy.
Radiat. Prot. Dosim. 13, 157-159 (1985)
In order to evaluate the efficiency of ultrasoft X rays in inducing DNA double strand breaks (DSB) yeast cells deficient in the repair of DSB (rad52 mutant) were irradiated with X rays generated at 2.0, 3.0, 4.0 and 7.0 kV using a silver anode and a Hostaphane foil as the window. Using the calculated photon spectra within the cell nucleus and the measured D0 values of the exponential survival curves of the rad52 mutant the RBE values for different photon energies were determined. The results show that the RBE value relative to 30 MeV electrons increases with decreasing photon energy and amounts to 2.0 for photons in the energy range from 1.1 to 1.5 keV. The direct determination of the mean number of DSB per cell for 2.0 kV and 4.0 kV X rays confirms results with 30 MeV electrons and 150 kV X rays that in the rad52 mutant one DSB is a lethal event.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 13,
Heft: 1-4,
Seiten: 157-159
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Abteilung Biophysikalische Strahlenforschung