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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Presence of cytochrome P-450- and cytochrome P-448-dependent monooxygenase functions in hepatoma cell lines.
Biochem. Biophys. Res. Commun. 94, 466-472 (1980)
Cell lines derived from Reuber H-4-II-E hepatoma cells and their hybrids that differ in the expression of liver-specific functions are shown to contain different forms of monooxygenases. According to the specificity toward the substrates benzo(a)pyrene, aldrin and chenodeoxycholic acid, the kinetics of the epoxidation of aldrin, the response to inducers, such as benz(a)anthracene and dexamethasone, and the in vitro modifier 7,8-benzoflavone, the monooxygenases predominating in differentiated cell lines belong to the cytochrome P-450-dependent enzyme(s), those in the less differentiated lines belong to the cytochrome P-448-dependent form(s).
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0006-291X
e-ISSN
1090-2104
Quellenangaben
Band: 94,
Heft: 2,
Seiten: 466-472
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Toxikologie und Biochemie