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Association of low C2 and C4 serum levels with the HLA-DW2 allele in healthy individuals.
J. Exp. Med. 148, 704-713 (1978)
HLA typed unrelated healthy individuals (HLA-DW2 positive n = 64, and HLA-DW2 negative n = 72) were investigated for their C2 functional activity and C4 serum protein levels. For the C2 and C4 levels a bimodal distribution was found in HLA-DW2 positive and HLA-DW2 negative individuals. HLA-DW2 positive persons had a significantly higher incidence of low C2 and C4 serum levels. Our data support the concept that genes governing C2 as well as C4 serum levels are in linkage disequilibrium with the HLA-DW2 allele of the major histocompatibility complex.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0022-1007
e-ISSN
1540-9538
Zeitschrift
Journal of Experimental Medicine
Quellenangaben
Band: 148,
Heft: 3,
Seiten: 704-713
Verlag
Rockefeller University Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Hämatologie