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Pharmacokinetics and hepatotoxicity of 2-nitropropane in rats.
Arch. Toxicol. 63, 330-332 (1989)
The solvent 2-nitropropane (2-NP) has been reported to produce liver necrosis and hepatocarcinoma in rats, males being much more sensitive than females (Griffin et al 1980). Since this may be caused by sex specific pharmacokinetics of 2-NP inhalation kinetics in male and in female Sprague-Dawley rats were investigated. Furthermore, as specific indicators of parenchymal hepatic injury the response of glutamic oxalacetic transaminase (GOT) and of glutamic pyruvic transaminase (GPT) was studied in serum after application of 2-NP to the animals.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0340-5761
e-ISSN
1432-0738
Konferenztitel
Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances
Zeitschrift
Archives of Toxicology
Quellenangaben
Band: 63,
Seiten: 330-332
Verlag
Springer
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed