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Quantitative determination of the contribution of indirect and direct radiation action to the production of lethal lesions in mammalian cells.
Radiat. Prot. Dosim. 13, 195-198 (1985)
For quantitative models of radiation action in living cells it is necessary to know what fraction of the absorbed dose affects the target molecule by direct radiation action and what fraction by indirect radiation action. Mammalian cells were irradiated in suspension, saturated with N2O or CO2. With these gases the production of OH-radicals is changed by a factor of two in aqueous solutions and a corresponding change in cell survival would be expected, if only indirect radiation action is involved in the production of lethal lesions in the living cell. No difference could be detected, however, and it is concluded that indirect radiation action does not contribute to radiation lethality in mammalian cells.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 13,
Heft: 1-4,
Seiten: 195-198
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Departments & Institutes