Laser light of low energy is discussed to have an accelerating effect on wound healing. The aim of the present study was to prove whether HeNe laser irradiations have a positive effect on regeneration of capillaries. For this purpose aluminium chambers were implanted in the dorsal skin flap of Syrian hamsters. After coagulation of blood vessels by means of an argon laser the tissue was irradiated daily with the low energy light of a HeNe laser. Regeneration of capillaries was studied by means of intravital microscopy. The results of the study revealed a positive effect of low dose HeNe laser irradiation on the regeneration of capillaries at day 5 after the coagulation. The measurable part of the capillaries was about 27% higher for the irradiated animals compared to controls.