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Osteosarcoma induced by short-lived bone-seeking α emitters in mice: The role of age.
Environ. Res. 18, 115-119 (1979)
In 3 experiments with low, medium, and high osteosarcoma expectancy after incorporation of 224Ra or 227Th the osteosarcoma risk of adult (5-6 mth old) female NMRI mice were compared with that of rapid growing (1 mth old) animals. Similar to results in the literature with other bone-seeking radionuclides the age-corrected osteosarcoma incidence was not significantly different in both age groups. In the experiment with high osteosarcoma risk the time of tumor appearance was mainly determined by the time of start of the internal irradiation period. It seems that at lower osteosarcoma expectancy the time of appearance of the tumors is mainly determined by the age of the animals.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0013-9351
e-ISSN
1096-0953
Zeitschrift
Environmental Research
Quellenangaben
Band: 18,
Heft: 1,
Seiten: 115-119
Verlag
Elsevier
Verlagsort
San Diego, Calif.
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Biologie