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Munker, R. ; Stünkel, K.G.E.

Characterization with monoclonal antibodies of human lymphocytes forming dog and rhesus-monkey rosettes.

Immunobiology 162, 78-85 (1982)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Human peripheral-blood mononuclear cells forming rosettes with dog and rhesus-monkey red blood cells was characterized with a double marker analysis combining immunofluorescence with a series of monoclonal antibodies and rosette formation. Dog rosette-forming cells are a minor subset of T cells which does not correspond to the helper or suppressor subsets of T cells as determined by the OKT antibodies. Dog rosette formation can be inhibited by two monoclonal antibodies directed against the receptor for sheep red blood cells on human lymphocytes. Rhesus-monkey rosettes can be formed by T lymphocytes as well as by monocytes, null cells, and B cells, as determined by the reactivities with the monoclonal antibodies OKM1 and anti-Ia. OKM1-positive cells are relatively enriched in these rosettes. No inhibition is seen with antibodies directed against the receptor for sheep red blood cells. In conclusion, we demonstrated with the use of monoclonal antibodies that dog and rhesus-monkey rosettes are qualitatively different phenomena.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0171-2985
e-ISSN 1878-3279
Zeitschrift Immunobiology : Experimental and Clinical
Quellenangaben Band: 162, Heft: 1, Seiten: 78-85 Artikelnummer: , Supplement: ,
Verlag Urban & Fischer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institut für Hämatologie