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Valent, P.* ; Horny, H.-P.* ; Bennett, J.M.* ; Fonatsch, C.* ; Germing, U.* ; Greenberg, P.* ; Haferlach, T.* ; Haase, D.* ; Kolb, H.-J. ; Krieger, O.* ; Loken, M.* ; van de Loosdrecht, A.* ; Ogata, K.* ; Orfao, A.* ; Pfeilstöcker, M.* ; Rüter, B.* ; Sperr, W.R.* ; Stauder, R.* ; Wells, D.A.*

Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: Consensus statements and report from a working conference.

Leuk. Res. 31, 727-736 (2007)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The classification, scoring systems, and response criteria for myelodysplastic syndromes (MDS) have recently been updated and have become widely accepted. In addition, several new effective targeted drugs for patients with MDS have been developed. The current article provides a summary of updated and newly proposed markers, criteria, and standards in MDS, with special reference to the diagnostic interface and refinements in evaluations and scoring. Concerning the diagnostic interface, minimal diagnostic criteria for MDS are proposed, and for patients with unexplained cytopenia who do not fulfill these criteria, the term ‘idiopathic cytopenia of uncertain significance’ (ICUS)next term is suggested. In addition, new diagnostic and prognostic parameters, histopathologic and immunologic determinants, proposed refinements in scoring systems, and new therapeutic approaches are discussed. Respective algorithms and recommendations should facilitate diagnostic and prognostic evaluations in MDS, selection of patients for therapies, and the conduct of clinical trials.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Myelodysplastic syndromes; Criteria; Standardization; Patient selection; ICUS; Minimal diagnostic criteria; Targeted therapy
Sprache englisch
Veröffentlichungsjahr 2007
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Zeitschrift Leukemia Research
Quellenangaben Band: 31, Heft: 6, Seiten: 727-736 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) CCG Hematopoetic Cell Transplants (IMI-KHZ)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-520300-001
PubMed ID 17257673
DOI 10.1016/j.leukres.2006.11.009
WOS ID 000247764200001
Erfassungsdatum 2007-12-31
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