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Höltz, G.W. ; Pohlit, W.

Unscheduled DNA synthesis in diploid yeast after x-irradiation in different phases of the cell-cycle.

Int. J. Radiat. Biol. 31, 121-129 (1977)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The uptake of radioactive 5'dTMP into the DNA of diploid yeast cells was measured in the G1 and S-phase of the cell-cycle. In control cells, the uptake is zero in G1 and increases with time in the S-phase. Cells irradiated in early G1 show an uptake (unscheduled DNA synthesis) which is higher than if irradiation is performed later in G1. An analysis which takes into consideration the incomplete synchronization of the cell population shows that, at the end of G1, no uptake would be present in an ideally-synchronous population. At the end of G1 the shoulder in the dose - effect curve for cell survival also disappears. This provides additional evidence that the shoulder in a dose - effect curve might be due to repair reactions in living cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0955-3002
e-ISSN 1362-3095
Zeitschrift International Journal of Radiation Biology
Quellenangaben Band: 31, Heft: 2, Seiten: 121-129 Artikelnummer: , Supplement: ,
Verlag Informa Healthcare
Begutachtungsstatus Peer reviewed
Institut(e) Abteilung Biophysikalische Strahlenforschung