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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Current aspects on the radiation induced base damage in DNA.
Radiat. Environ. Biophys. 25, 261-271 (1986)
In this review, some current aspects of our knowledge about base damage in DNA induced by ionizing radiation will be summarized. The understanding of DNA base damage requires the analysis of radicals formed in irradiated single DNA moieties as well as in whole DNA. Chemical studies about can be used for the molecular alterations of bases and biochemical methods for DNA-sequencing. In addition enzymes recognizing DNA damage and immunological methods with specific antibodies can be employed. However special emphasis should be given to the analysis of DNA base damage in irradiated cells and it will be shown, that a distinct gap in knowledge exists in this field in contrast to the radiation chemistry in aqueous solutions of DNA.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Zeitschrift
Radiation and Environmental Biophysics
Quellenangaben
Band: 25,
Heft: 4,
Seiten: 261-271
Verlag
Springer
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Biology (ISB)