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Betz, H.

Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells.

Biochem. Biophys. Res. Commun. 72, 114-120 (1976)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In exponentially growing cells of Saccharomyces, cerevisiae, cycloheximide stimulated intracellular protein degradation to the same extent as did starvation for required amino acids. By using inhibitors of macromolecular synthesis and temperature-sensitive mutants defective in different steps of RNA and protein synthesis it could be demonstrated, that this stimulation of protein degradation was directly related to the inhibition of protein synthesis per se, but not connected to the cessation of ribosomal RNA synthesis or to the inhibition of cell growth.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0006-291X
e-ISSN 1090-2104
Zeitschrift Biochemical and Biophysical Research Communications
Quellenangaben Band: 72, Heft: 1, Seiten: 114-120 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institut für Biochemie