PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Seemann, K.M.* ; Luysberg, M.* ; Revay, Z.* ; Kudejova, P.* ; Sague, B.S.* ; Cassinelli, N.* ; Loidl, A.* ; Ilicic, K.* ; Multhoff, G. ; Schmid, T.E.

Magnetic heating properties and neutron activation of tungsten-oxide coated biocompatible FePt core-shell nanoparticles.

J. Control. Release 197, 131-137 (2014)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Magnetic nanoparticles are highly desirable for biomedical research and treatment of cancer especially when combined with hyperthermia. The efficacy of nanoparticle-based therapies could be improved by generating radioactive nanoparticles with a convenient decay time and which simultaneously have the capability to be used for locally confined heating. The core–shell morphology of such novel nanoparticles presented in this work involves a polysilico-tungstate molecule of the polyoxometalate family as a precursor coating material, which transforms into an amorphous tungsten oxide coating upon annealing of the FePt core–shell nanoparticles. The content of tungsten atoms in the nanoparticle shell is neutron activated using cold neutrons at the Heinz Maier-Leibnitz (FRMII) neutron facility and thereby transformed into the radioisotope W-187. The sizeable natural abundance of 28% for the W-186 precursor isotope, a radiopharmaceutically advantageous gamma–beta ratio of γβ≈30% and a range of approximately 1 mm in biological tissue for the 1.3 MeV β-radiation are promising features of the nanoparticles' potential for cancer therapy. Moreover, a high temperature annealing treatment enhances the magnetic moment of nanoparticles in such a way that a magnetic heating effect of several degrees Celsius in liquid suspension – a prerequisite for hyperthermia treatment of cancer – was observed. A rise in temperature of approximately 3 °C in aqueous suspension is shown for a moderate nanoparticle concentration of 0.5 mg/ml after 15 min in an 831 kHz high-frequency alternating magnetic field of 250 Gauss field strength (25 mT). The biocompatibility based on a low cytotoxicity in the non-neutron-activated state in combination with the hydrophilic nature of the tungsten oxide shell makes the coated magnetic FePt nanoparticles ideal candidates for advanced radiopharmaceutical applications.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.261
2.036
22
20
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nanoparticles ; Core-shell ; Fept ; Polyoxometalates ; Hyperthermia ; Neutron Activation
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0168-3659
e-ISSN 1873-4995
Zeitschrift Journal of Controlled Release
Quellenangaben Band: 197, Heft: , Seiten: 131-137 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-521400-001
DOI 10.1016/j.jconrel.2014.11.007
WOS ID WOS:000346568700015
Erfassungsdatum 2014-11-27
[➜Korrektur melden]