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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Magnetic heating properties and neutron activation of tungsten-oxide coated biocompatible FePt core-shell nanoparticles.
J. Control. Release 197, 131-137 (2014)
Magnetic nanoparticles are highly desirable for biomedical research and treatment of cancer especially when combined with hyperthermia. The efficacy of nanoparticle-based therapies could be improved by generating radioactive nanoparticles with a convenient decay time and which simultaneously have the capability to be used for locally confined heating. The core–shell morphology of such novel nanoparticles presented in this work involves a polysilico-tungstate molecule of the polyoxometalate family as a precursor coating material, which transforms into an amorphous tungsten oxide coating upon annealing of the FePt core–shell nanoparticles. The content of tungsten atoms in the nanoparticle shell is neutron activated using cold neutrons at the Heinz Maier-Leibnitz (FRMII) neutron facility and thereby transformed into the radioisotope W-187. The sizeable natural abundance of 28% for the W-186 precursor isotope, a radiopharmaceutically advantageous gamma–beta ratio of γβ≈30% and a range of approximately 1 mm in biological tissue for the 1.3 MeV β-radiation are promising features of the nanoparticles' potential for cancer therapy. Moreover, a high temperature annealing treatment enhances the magnetic moment of nanoparticles in such a way that a magnetic heating effect of several degrees Celsius in liquid suspension – a prerequisite for hyperthermia treatment of cancer – was observed. A rise in temperature of approximately 3 °C in aqueous suspension is shown for a moderate nanoparticle concentration of 0.5 mg/ml after 15 min in an 831 kHz high-frequency alternating magnetic field of 250 Gauss field strength (25 mT). The biocompatibility based on a low cytotoxicity in the non-neutron-activated state in combination with the hydrophilic nature of the tungsten oxide shell makes the coated magnetic FePt nanoparticles ideal candidates for advanced radiopharmaceutical applications.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Nanoparticles ; Core-shell ; Fept ; Polyoxometalates ; Hyperthermia ; Neutron Activation
ISSN (print) / ISBN
0168-3659
e-ISSN
1873-4995
Zeitschrift
Journal of Controlled Release
Quellenangaben
Band: 197,
Seiten: 131-137
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Innate Immunity in Tumor Biology (IBMI-KTB)