PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Conrad, M. ; Ingold, I. ; Buday, K. ; Kobayashi, S. ; Friedmann Angeli, J.P.F.

ROS, thiols and thiol-regulating systems in male gametogenesis.

Biochim. Biophys. Acta-Gen. Subj. 1850, 1566-1574 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: During maturation and storage, spermatozoa generate substantial amounts of reactive oxygen species (ROS) and are thus forced to cope with an increasing oxidative environment that is both needed and detrimental to their biology. Such a janus-faceted intermediate needs to be tightly controlled and this is done by a wide array of redox enzymes. These enzymes not only have to prevent unspecific modifications of essential cellular biomolecules by quenching undesired ROS, but they are required and often directly involved in critical protein modifications. SCOPE OF REVIEW: The present review is conceived to present an update on what is known about critical roles of redox enzymes, whereby special emphasis is put on the family of glutathione peroxidases, which for the time being present the best characterized tasks during gametogenesis. MAJOR CONCLUSIONS: We therefore demonstrate that understanding the function of (seleno)thiol-based oxidases/reductases is not a trivial task and relevant knowledge will be mainly gained by using robust systems, as exemplified by several (conditional) knockout studies. We thus stress the importance of using such models for providing unequivocal evidence in the molecular understanding of redox regulatory mechanisms in sperm maturation. GENERAL SIGNIFICANCE: ROS are not only detrimental by-products of metabolism and its proper generation and usage by specific enzymes is essential for vital functions as beautifully exemplified during male gametogenesis. As such, lessons learnt from thiol-based oxidases/reductases in male gametogenesis could be used as a general principle for other organs as it is most likely not only restricted to this developmental phase. This article is part of a Special Issue entitled Redox regulation of differentiation and de-differentiation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.381
1.290
20
25
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Glutathione Peroxidase ; Oxidative Stress ; Selenium ; Selenoproteins ; Spermatogenesis; Hydroperoxide Glutathione-peroxidase; Mitochondrial Thioredoxin Reductase; Early Embryonic Lethality; Disulfide Bond Formation; Oxidative Stress; Reactive Oxygen; Cell-death; Superoxide-dismutase; Human-spermatozoa; Sperm Maturation
Sprache
Veröffentlichungsjahr 2015
Prepublished im Jahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0304-4165
e-ISSN 1872-8006
Zeitschrift Biochimica et Biophysica Acta - General Subjects
Quellenangaben Band: 1850, Heft: 8, Seiten: 1566-1574 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-004
G-500500-001
PubMed ID 25450170
DOI 10.1016/j.bbagen.2014.10.020
WOS ID WOS:000355895100010
Scopus ID 84929358937
Erfassungsdatum 2014-12-04
[➜Korrektur melden]