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Gottschalk, S. ; Fehm, T. ; Dean-Ben, X.L. ; Razansky, D.

Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography.

J. Cereb. Blood Flow Metab. 35, 531-535 (2015)
Postprint DOI PMC
Open Access Green
Current functional neuroimaging methods are not adequate for high-resolution whole-brain visualization of neural activity in real time. Here, we show imaging of fast hemodynamic changes in deep mouse brain using fully noninvasive acquisition of five-dimensional optoacoustic data from animals subjected to oxygenation stress. Multispectral video-rate acquisition of three-dimensional tomographic data enables simultaneous label-free assessment of multiple brain hemodynamic parameters, including blood oxygenation, total hemoglobin, cerebral blood volume, oxygenized and deoxygenized hemoglobin, in real time. The unprecedented results indicate that the proposed methodology may serve as a powerful complementary, and potentially superior, method for functional neuroimaging studies in rodents.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Cerebral Hemodynamics ; Functional Neuroimaging ; Neuroimaging ; Optoacoustic/photoacoustic Tomography ; Real Time; In-vivo; Blood-flow; Metabolism; Microscopy; Vasculature; Oxygenation; Dynamics
ISSN (print) / ISBN 0271-678X
e-ISSN 1559-7016
Zeitschrift Journal of Cerebral Blood Flow & Metabolism
Quellenangaben Band: 35, Heft: 4, Seiten: 531-535 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)