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Holzerova, E. ; Prokisch, H.

Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?

Int. J. Biochem. Cell Biol. 63, 16-20 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
For more than 50 years, reactive oxygen species have been considered as harmful agents, which can attack proteins, lipids or nucleic acids. In order to deal with reactive oxygen species, there is a sophisticated system developed in mitochondria to prevent possible damage. Indeed, increased reactive oxygen species levels contribute to pathomechanisms in several human diseases, either by its impaired defense system or increased production of reactive oxygen species. However, in the last two decades, the importance of reactive oxygen species in many cellular signaling pathways has been unraveled. Homeostatic levels were shown to be necessary for correct differentiation during embryonic expansion of stem cells. Although the mechanism is still not fully understood, we cannot only regard reactive oxygen species as a toxic by-product of mitochondrial respiration anymore.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ros Scavenging ; Ros Signalization ; Reactive Oxygen Species; Protein-tyrosine Phosphatases; Hydrogen-peroxide; Redox Regulation; Complex Iii; Superoxide; Dehydrogenase; Thioredoxin; Inactivation; Generation; Apoptosis
ISSN (print) / ISBN 1357-2725
e-ISSN 1878-5875
Zeitschrift International Journal of Biochemistry & Cell Biology, The
Quellenangaben Band: 63, Heft: , Seiten: 16-20 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)