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Medrikova, D.* ; Sijmonsma, T.P.* ; Sowodniok, K.* ; Richards, D.M.* ; Delacher, M.* ; Sticht, C.* ; Gretz, N.* ; Schafmeier, T. ; Feuerer, M.* ; Herzig, S.

Brown adipose tissue harbors a distinct sub-population of regulatory T cells.

PLoS ONE 10:e0118534 (2015)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Insulin-resistance; Adipocytes; Obesity; Macrophages; Thermogenesis; Inflammation; Activation; Mice; Recruitment; Expression
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 10, Heft: 2, Seiten: , Artikelnummer: e0118534 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)