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Rosewich, M.* ; Zissler, U.M. ; Kheiri, T.* ; Voss, S.* ; Eickmeier, O.* ; Schulze, J.* ; Herrmann, E.* ; Dücker, R.P.* ; Schubert, R.* ; Zielen, S.*

Airway inflammation in children and adolescents with bronchiolitis obliterans.

Cytokine 73, 156-162 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Airway inflammation plays a major role in the progression of chronic lung diseases. The features of airway inflammation are not well defined among patients with cases of bronchiolitis obliterans (BO) that began in childhood. OBJECTIVES: To investigate the sputum cell and cytokine profiles of stable cases of BO regarding lung function and the involvement of small airway disease (SAD). METHODS: Twenty patients with BO (median age=14.5, range=7-23years) and 22 healthy controls (median age=16.5years, range=7-24years) were investigated. Lung function parameters and bronchial reversibility testing as well as sputum cell and cytokine profiles (IL-1β, IL-6, IL-8, TNF-α, IL-5, IFN-γ, and NFκB regulation) were analysed using quantitative RT-PCR and cytometric bead assay (CBA) in induced sputum. RESULTS: Patients with BO had significantly lower lung function values, including FVC, forced expiratory volume (FEV1), the Tiffeneau index (FEV1/VC), and MEF25, but increased functional residual capacity (RV/TLC) values. Bronchial reversibility was found in five patients (25%). Moreover, airway inflammation (as indicated by total cells, neutrophils, IL-1β, IL-6, IL-8, TNF-α, and NFκB) was significantly increased among patients with BO compared with controls. CONCLUSIONS: BO is predominantly a neutrophilic disease of the small bronchioles featuring elevated levels of pro-inflammatory cytokines leading to tissue remodelling and fibrosis of the small airways. Future therapies for patients with BO should more efficiently target the small airways.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Bronchiolitis Obliterans ; Paediatric Interstitial Lung Disease ; Rare Lung Diseases ; Sputum; Stem-cell Transplantation; Exhaled Nitric-oxide; Cystic-fibrosis; Bronchoalveolar Lavage; Lung Transplantation; Oxidative Stress; Asthma; Disease; Interleukin-8; Neutrophilia
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1043-4666
e-ISSN 1096-0023
Zeitschrift Cytokine
Quellenangaben Band: 73, Heft: 1, Seiten: 156-162 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Oxford [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-505400-001
PubMed ID 25748838
DOI 10.1016/j.cyto.2014.10.026
WOS ID WOS:000353078500022
Scopus ID 84924093787
Erfassungsdatum 2015-03-11
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