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Attia, A.B.E.* ; Balasundaram, G.* ; Driessen, W.H.P. ; Ntziachristos, V. ; Olivo, M.*

Phthalocyanine photosensitizers as contrast agents for in vivo photoacoustic tumor imaging.

Biomed. Opt. Express 6, 591-598 (2015)
Verlagsversion DOI PMC
Open Access Gold
There is a need for contrast agents for non-invasive diagnostic imaging of tumors. Herein, Multispectral Optoacoustic Tomography (MSOT) was employed to evaluate phthalocyanines commonly used in photodynamic therapy as photoacoustic contrast agents. We studied the photoacoustic activity of three water-soluble phthalocyanine photosensitizers: phthalocyanine tetrasulfonic acid (PcS4), Zn(II) phthalocyanine tetrasulfonic acid (ZnPcS4) and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) in phantom and in tumor-bearing mice to investigate the biodistribution and fate of the phthalocyanines in the biological tissues. PcS4 was observed to grant good contrast between the different reticuloendothelial organs and accumulate in the tumor within an hour of post-administration. ZnPcS4 and AlPcS4 offered little contrast in photoacoustic signals between the organs. PcS4 is a promising photoacoustic contrast agent and can be exploited as a photodiagnostic agent.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter (110.4234) Multispectral And Hyperspectral Imaging ; (110.5125) Photoacoustics ; (160.1050) Acousto-optical Materials ; (170.3880) Medical And Biological Imaging ; (170.5120) Photoacoustic Imaging ; (170.6930) Tissue; Zinc Phthalocyanine; Fluorescence Kinetics; Photodynamic Therapy; Tomography; Model
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 2156-7085
e-ISSN 2156-7085
Zeitschrift Biomedical Optics Express
Quellenangaben Band: 6, Heft: 2, Seiten: 591-598 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 25780748
DOI 10.1364/BOE.6.000591
WOS ID WOS:000349455700025
Erfassungsdatum 2015-04-05
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