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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Microfluidics for sperm research.
Trends Biotechnol. 33, 221-229 (2015)
One in six couples of reproductive age worldwide are affected at least once by some form of infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are widely-available assisted reproductive technologies (ART). The identification and isolation of the most-motile sperm with DNA integrity are essential to IVF and ICSI, ultimately affecting treatment consequences and the health of offspring. Recently, microfluidic technologies been developed to sort sperm according to sperm morphology, motility, DNA integrity, and functionality for IVF techniques. There have also been emerging applications in wildlife conservation, high-throughput single-sperm genomics, sperm-driven robotics, and in-home fertility testing. We review a broad range of studies applying the principles of microfluidics to sperm research.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Microfluidics ; Point-of-care ; Sperm Genomics ; Sperm Sorting For Infertility ; Sperm-driven Robotics ; Wildlife Conservation; Single-cell Analysis; On-chip; Dna Integrity; Motile Sperm; Device; Chemotaxis; Health; Future; Technologies; Trajectories
ISSN (print) / ISBN
0167-7799
e-ISSN
1879-3096
Zeitschrift
Trends in Biotechnology
Quellenangaben
Band: 33,
Heft: 4,
Seiten: 221-229
Verlag
Elsevier
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed