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Knowlton, S.M.* ; Sadasivam, M. ; Tasoglu, S.*

Microfluidics for sperm research.

Trends Biotechnol. 33, 221-229 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
One in six couples of reproductive age worldwide are affected at least once by some form of infertility. In vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are widely-available assisted reproductive technologies (ART). The identification and isolation of the most-motile sperm with DNA integrity are essential to IVF and ICSI, ultimately affecting treatment consequences and the health of offspring. Recently, microfluidic technologies been developed to sort sperm according to sperm morphology, motility, DNA integrity, and functionality for IVF techniques. There have also been emerging applications in wildlife conservation, high-throughput single-sperm genomics, sperm-driven robotics, and in-home fertility testing. We review a broad range of studies applying the principles of microfluidics to sperm research.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Microfluidics ; Point-of-care ; Sperm Genomics ; Sperm Sorting For Infertility ; Sperm-driven Robotics ; Wildlife Conservation; Single-cell Analysis; On-chip; Dna Integrity; Motile Sperm; Device; Chemotaxis; Health; Future; Technologies; Trajectories
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0167-7799
e-ISSN 1879-3096
Zeitschrift Trends in Biotechnology
Quellenangaben Band: 33, Heft: 4, Seiten: 221-229 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
PubMed ID 25798781
DOI 10.1016/j.tibtech.2015.01.005
WOS ID WOS:000352679500006
Scopus ID 84925291393
Scopus ID 84924956327
Erfassungsdatum 2015-03-25
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