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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Thiol switches in mitochondria: Operation and physiological relevance.
Biol. Chem. 396, 465-482 (2015)
Verlagsversion
DOI
PMC
Mitochondria are a major source of reactive oxygen species (ROS) in the cell, particularly of superoxide and hydrogen peroxide. A number of dedicated enzymes regulate the conversion and consumption of superoxide and hydrogen peroxide in the intermembrane space and the matrix of mitochondria. Nevertheless, hydrogen peroxide can also interact with many other mitochondrial enzymes, particularly those with reactive cysteine residues, modulating their reactivity in accordance with changes in redox conditions. In this review we will describe the general redox systems in mitochondria of animals, fungi and plants and discuss potential target proteins that were proposed to contain regulatory thiol switches.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Glutathione ; Hydrogen Peroxide ; Mitochondria ; Nadph ; Reactive Oxygen Species ; Redox Regulation ; Ros ; Signaling ; Thiol Switch; Branched-chain Aminotransferase; Muscle Creatine-kinase; Resistant Alternative Oxidase; Ischemia-reperfusion Injury; Ascorbate-glutathione Cycle; Disulfide Bond Formation; Respiratory Complex-i; Active-site Cysteine; Intermembrane Space; Oxidative Stress
ISSN (print) / ISBN
1431-6730
e-ISSN
1437-4315
Zeitschrift
Biological Chemistry
Quellenangaben
Band: 396,
Heft: 5,
Seiten: 465-482
Verlag
de Gruyter
Verlagsort
Berlin
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Developmental Genetics (IDG)