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Riemer, J.* ; Schwarzländer, M.* ; Conrad, M. ; Herrmann, J.M.*

Thiol switches in mitochondria: Operation and physiological relevance.

Biol. Chem. 396, 465-482 (2015)
Verlagsversion DOI PMC
Open Access Gold
Mitochondria are a major source of reactive oxygen species (ROS) in the cell, particularly of superoxide and hydrogen peroxide. A number of dedicated enzymes regulate the conversion and consumption of superoxide and hydrogen peroxide in the intermembrane space and the matrix of mitochondria. Nevertheless, hydrogen peroxide can also interact with many other mitochondrial enzymes, particularly those with reactive cysteine residues, modulating their reactivity in accordance with changes in redox conditions. In this review we will describe the general redox systems in mitochondria of animals, fungi and plants and discuss potential target proteins that were proposed to contain regulatory thiol switches.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Glutathione ; Hydrogen Peroxide ; Mitochondria ; Nadph ; Reactive Oxygen Species ; Redox Regulation ; Ros ; Signaling ; Thiol Switch; Branched-chain Aminotransferase; Muscle Creatine-kinase; Resistant Alternative Oxidase; Ischemia-reperfusion Injury; Ascorbate-glutathione Cycle; Disulfide Bond Formation; Respiratory Complex-i; Active-site Cysteine; Intermembrane Space; Oxidative Stress
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Zeitschrift Biological Chemistry
Quellenangaben Band: 396, Heft: 5, Seiten: 465-482 Artikelnummer: , Supplement: ,
Verlag de Gruyter
Verlagsort Berlin
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-004
PubMed ID 25720067
DOI 10.1515/hsz-2014-0293
WOS ID WOS:000352810300006
Scopus ID 84927939726
Erfassungsdatum 2015-04-05
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