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Kälin, S. ; Heppner, F.L.* ; Bechmann, I.* ; Prinz, M.* ; Tschöp, M.H. ; Yi, C.-X.*

Hypothalamic innate immune reaction in obesity.

Nat. Rev. Endocrinol. 11, 339–351 (2015)
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Findings from rodent and human studies show that the presence of inflammatory factors is positively correlated with obesity and the metabolic syndrome. Obesity-associated inflammatory responses take place not only in the periphery but also in the brain. The hypothalamus contains a range of resident glial cells including microglia, macrophages and astrocytes, which are embedded in highly heterogenic groups of neurons that control metabolic homeostasis. This complex neural-glia network can receive information directly from blood-borne factors, positioning it as a metabolic sensor. Following hypercaloric challenge, mediobasal hypothalamic microglia and astrocytes enter a reactive state, which persists during diet-induced obesity. In established mouse models of diet-induced obesity, the hypothalamic vasculature displays angiogenic alterations. Moreover, proopiomelanocortin neurons, which regulate food intake and energy expenditure, are impaired in the arcuate nucleus, where there is an increase in local inflammatory signals. The sum total of these events is a hypothalamic innate immune reactivity, which includes temporal and spatial changes to each cell population. Although the exact role of each participant of the neural-glial-vascular network is still under exploration, therapeutic targets for treating obesity should probably be linked to individual cell types and their specific signalling pathways to address each dysfunction with cell-selective compounds.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Nf-kappa-b; Necrosis-factor-alpha; Diet-induced Obesity; High-fat-diet; Glucose-transporter Proteins; Induced Insulin-resistance; Central-nervous-system; Cns Myeloid Cells; Alzheimers-disease; Energy-balance
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Zeitschrift Nature Reviews - Endocrinology
Quellenangaben Band: 11, Heft: 6, Seiten: 339–351 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
G-501900-228
PubMed ID 25824676
DOI 10.1038/nrendo.2015.48
WOS ID WOS:000354807700009
Erfassungsdatum 2015-04-02
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