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Berrios, C.* ; Jung, J.U.* ; Primi, B.* ; Wang, M.* ; Pedamallu, C.* ; Duke, F.* ; Marcelus, C.* ; Cheng, J.* ; Garcea, R.L.* ; Meyerson, M.* ; DeCaprio, J.A.* ; TEDDY Study Group (Ziegler, A.-G. ; Beyerlein, A. ; Henneberger, L. ; Hummel, M. ; Hummel, S. ; Knopff, A. ; Krause, S. ; Peplow, C. ; Pflüger, M. ; Roth, R. ; Schenkel, J. ; Stock, J. ; Strauss, E. ; Warncke, K. ; Winkler, C.)

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.

J. Virol. 89, 857-862 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Merkel Cell Polyomavirus; Small-t-antigen; African-green Monkey; Protein Phosphatase-2a; Genome; Identification; Transformation; Complexes; Disease; P53
ISSN (print) / ISBN 0022-538X
e-ISSN 1098-5514
Zeitschrift Journal of Virology
Quellenangaben Band: 89, Heft: 1, Seiten: 857-862 Artikelnummer: , Supplement: ,
Verlag American Society for Microbiology (ASM)
Verlagsort Washington
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)