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Peters, A. ; Hampel, R. ; Cyrys, J. ; Breitner-Busch, S. ; Geruschkat, U. ; Kraus, U. ; Zareba, W.* ; Schneider, A.E.

Elevated particle number concentrations induce immediate changes in heart rate variability: A panel study in individuals with impaired glucose metabolism or diabetes.

Part. Fibre Toxicol. 12:7 (2015)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Background The health effects of short-term exposure to ambient ultrafine particles in micro-environments are still under investigation. Methods Sixty-four individuals with type 2 diabetes and impaired glucose tolerance recorded ambulatory electrocardiograms over five to six hours on 191 occasions in a panel study in Augsburg, Germany. Personal exposure to particle number concentrations (PNC) was monitored for each individual on 5-minute basis concurrently and particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5) was acquired from a central monitoring site on an hourly basis. Results More than 11,000 5-minute intervals were available for heart rate and measures of heart rate variability including SDNN (standard deviation of NN intervals). A concurrent decrease in 5-minute SDNN of −0.56% (95% confidence limits (CI): −1.02%; −0.09%) and a 5-minute delayed increase in heart rate of 0.23 % (95% CI: 0.11%; 0.36%) was observed with an increase in personal PNC of 16,000 per cm3 in additive mixed models. Models evaluating the association of concurrent 5-minute personal PNC and of 1-hour PM2.5 showed independent effects on SDNN. Conclusion The data suggest that freshly emitted ultrafine particles and aged fine particulate matter are both associated with changes in cardiac function in individuals with type 2 diabetes and impaired glucose tolerance in urban areas.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Epidemiological study; Heart rate variability; Personal exposure; Type 2 diabetes; Ultrafine particles; Particulate Air-pollution; Coronary-artery-disease; Young Healthy-adults; Long-term Exposure; Myocardial-infarction; Personal Exposure; Ultrafine Particles; Airborne Particles; Ambient Ultrafine; Sized Particles
ISSN (print) / ISBN 1743-8977
e-ISSN 1743-8977
Zeitschrift Particle and Fibre Toxicology
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 7 Supplement: ,
Verlag BioMed Central
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)