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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mechanistic modelling of radiation-induced bystander effects.
Radiat. Prot. Dosim. 166, 148-151 (2015)
A model of radiation-induced bystander effects is presented that explicitly takes into account the transient nature of bystander signal emission post-irradiation, signal lifetime and the non-linear cellular response to the signals. Data are analysed on mutagenesis induced in human lymphoblasts in medium transfer experiments, in which the signal build-up time, medium dilution and the duration of reporter cells' exposure to the medium were varied. The model implies that the cellular release of bystander signals decreases rather slowly, with a characteristic time of about a day, whereas the signal itself decays with a lifetime of about an hour.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 166,
Heft: 1-4,
Seiten: 148-151
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)