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Clemmensen, C. ; Müller, T.D. ; Finan, B. ; Tschöp, M.H. ; DiMarchi, R.*

Current and emerging treatment options in diabetes care.

Handb. Exp. Pharmacol. 233, 437-459 (2016)
Postprint DOI PMC
Open Access Green
Diabetes constitutes an increasing threat to human health, particularly in newly industrialized and densely populated countries. Type 1 and type 2 diabetes arise from different etiologies but lead to similar metabolic derangements constituted by an absolute or relative lack of insulin that results in elevated plasma glucose. In the last three decades, a set of new medicines built upon a deeper understanding of physiology and diabetic pathology have emerged to enhance the clinical management of the disease and related disorders. Recent insights into insulin-dependent and insulin-independent molecular events have accelerated the generation of a series of novel medicinal agents, which hold the promise for further advances in the management of diabetes. In this chapter, we provide a historical context for what has been accomplished to provide perspective for future research and novel emerging treatment options.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Co-agonist ; Combination Therapies ; Diabetes ; Glucose ; Insulin ; Metabolism ; Obesity ; Pharmacology ; Therapeutics
Sprache englisch
Veröffentlichungsjahr 2016
Prepublished im Jahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0171-2004
Zeitschrift Handbook of Experimental Pharmacology
Quellenangaben Band: 233, Heft: , Seiten: 437-459 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
G-501900-221
DOI 10.1007/164_2015_7
Scopus ID 84961671404
PubMed ID 25903416
Erfassungsdatum 2015-04-25
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