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Volaklis, K.A.* ; Halle, M.R.* ; Meisinger, C.

Muscular strength as a strong predictor of mortality: A narrative review.

Eur. J. Intern. Med. 26, 303-310 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Muscular strength, an important component of physical fitness, has an independent role in the prevention of chronic diseases whereas muscular weakness is strongly related to functional limitations and physical disability. Our purpose was to investigate the role of muscular strength as a predictor of mortality in health and disease. We conducted a systematic search in EMBASE and MEDLINE (1980-2014) looking for the association between muscular strength and mortality risk (all-cause and cause-specific mortality). Selected publications included 23 papers (15 epidemiological and 8 clinical studies). Muscular strength was inversely and independently associated with all-cause mortality even after adjusting for several confounders including the levels of physical activity or even cardiorespiratory fitness. The same pattern was observed for cardiovascular mortality; however more research is needed due to the few available data. The existed studies failed to show that low muscular strength is predictive of cancer mortality. Furthermore, a strong and inverse association of muscular strength with all-cause mortality has also been confirmed in several clinical populations such as cardiovascular disease, peripheral artery disease, cancer, renal failure, chronic obstructive pulmonary disease, rheumatoid arthritis and patients with critical illness. However, future studies are needed to further establish the current evidence and to explore the exact independent mechanisms of muscular strength in relation to mortality. Muscular strength as a modifiable risk factor would be of great interest from a public health perspective.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Disease ; Epidemiology ; Health ; Mortality ; Muscular Strength ; Risk Factor; All-cause Mortality; Peripheral Arterial-disease; American-heart-association; Skeletal-muscle Mass; Hand Grip Strength; Length-of-stay; Physical-activity; Cardiovascular-disease; Cardiorespiratory Fitness; Resistance Exercise
ISSN (print) / ISBN 0953-6205
e-ISSN 1879-0828
Zeitschrift European Journal of Internal Medicine
Quellenangaben Band: 26, Heft: 5, Seiten: 303-310 Artikelnummer: , Supplement: ,
Verlag Pozzi
Verlagsort Roma
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)