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Tischer, C.G. ; Zock, J.P.* ; Valkonen, M.* ; Doekes, G.* ; Guerra, S.* ; Heederik, D.* ; Jarvis, D.* ; Norbäck, D.* ; Olivieri, M.* ; Sunyer, J.* ; Svanes, C.* ; Täubel, M.* ; Thiering, E. ; Verlato, G.* ; Hyvärinen, A.* ; Heinrich, J.

Predictors of microbial agents in dust and respiratory health in the Ecrhs.

BMC Pulm. Med. 15:48 (2015)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to assess predictors of microbial agents in mattress dust throughout Europe and to investigate associations between microbial exposures, home characteristics and respiratory health. METHODS: Seven different fungal and bacterial parameters were assessed in mattress dust from 956 adult ECRHS II participants in addition to interview based home characteristics. Associations between microbial parameters and the asthma score and lung function were examined using mixed negative binomial regression and linear mixed models, respectively. RESULTS: Indoor dampness and pet keeping were significant predictors for higher microbial agent concentrations in mattress dust. Current mould and condensation in the bedroom were significantly associated with lung function decline and current mould at home was positively associated with the asthma score. Higher concentrations of muramic acid were associated with higher mean ratios of the asthma score (aMR 1.37, 95%CI 1.17-1.61). There was no evidence for any association between fungal and bacterial components and lung function. CONCLUSION: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Airways ; Asthma ; Fungi ; Indoor Air ; Microbials ; Molds; In-house Dust; Allergic Sensitization; Asthma Symptoms; Cat Allergen; Risk-factors; Endotoxin; Exposure; Determinants; Childhood; Children
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
e-ISSN 1471-2466
Zeitschrift BMC Pulmonary Medicine
Quellenangaben Band: 15, Heft: 1, Seiten: , Artikelnummer: 48 Supplement: ,
Verlag BioMed Central
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
PubMed ID 25929252
DOI 10.1186/s12890-015-0042-y
WOS ID WOS:000354161600001
Scopus ID 84928995476
Scopus ID 84928963994
Erfassungsdatum 2015-05-03
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