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Kreuzer, M.* ; Auvinen, A.* ; Cardis, E.* ; Hall, J.* ; Jourdain, J.R.* ; Laurier, D.* ; Little, M.P.* ; Peters, A. ; Raj, K.* ; Russell, N.S.* ; Tapio, S. ; Zhang, W.* ; Gomolka, M.*

Low-dose ionising radiation and cardiovascular diseases – strategies for molecular epidemiological studies in Europe.

Mutat. Res.- Rev. Mutat. Res. 764, 90-100 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
It is well established that high-dose ionising radiation causes cardiovascular diseases. In contrast, the evidence for a causal relationship between long-term risk of cardiovascular diseases after moderate doses (0.5–5 Gy) is suggestive and weak after low doses (<0.5 Gy). However, evidence is emerging that doses under 0.5 Gy may also increase long-term risk of cardiovascular disease. This would have major implications for radiation protection with respect to medical use of radiation for diagnostic purposes and occupational or environmental radiation exposure. Therefore, it is of great importance to gain information about the presence and possible magnitude of radiation-related cardiovascular disease risk at doses of less than 0.5 Gy. The biological mechanisms implicated in any such effects are unclear and results from epidemiological studies are inconsistent. Molecular epidemiological studies can improve the understanding of the pathogenesis and the risk estimation of radiation-induced circulatory disease at low doses. Within the European DoReMi (Low Dose Research towards Multidisciplinary Integration) project, strategies to conduct molecular epidemiological studies in this field have been developed and evaluated. Key potentially useful European cohorts are the Mayak workers, other nuclear workers, uranium miners, Chernobyl liquidators, the Techa river residents and several diagnostic or low-dose radiotherapy patient cohorts. Criteria for informative studies are given and biomarkers to be investigated suggested. A close collaboration between epidemiology, biology and dosimetry is recommended, not only among experts in the radiation field, but also those in cardiovascular diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Epidemiology; Biomarker; Ionising radiation; Cardiovascular diseases; Pathogenesis; Atomic-bomb Survivors; Ischemic-heart-disease; Coronary-artery-disease; Irradiated Mouse Kidney; Uranium Miners Cohort; C-reactive Protein; Blood-pressure; Circulatory Disease; Systematic Analysis; Endothelial-cells
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1383-5742
e-ISSN 1388-2139
Zeitschrift Mutation Research / Reviews in Mutation Research
Quellenangaben Band: 764, Heft: , Seiten: 90-100 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)
Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Radiation Sciences
Genetics and Epidemiology
PSP-Element(e) G-500200-001
G-504000-001
PubMed ID 26041268
DOI 10.1016/j.mrrev.2015.03.002
WOS ID WOS:000357349700007
Scopus ID 84930045539
Erfassungsdatum 2015-05-15
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