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Wolf, K. ; Schneider, A.E. ; Breitner-Busch, S. ; Meisinger, C. ; Heier, M. ; Cyrys, J. ; Kuch, B.* ; von Scheidt, W.* ; Peters, A. ; KORA Study Group (Gieger, C. ; Grallert, H. ; Heinrich, J. ; Holle, R. ; Leidl, R. ; Strauch, K.)

Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany.

Int. J. Hyg. Environ. Health 218, 535-542 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Short-term exposure to increased particulate matter (PM) concentration has been reported to trigger myocardial infarction (MI). However, the association with ultrafine particles remains unclear. OBJECTIVES: We aimed to assess the effects of short-term air pollution and especially ultrafine particles on registry-based MI events and coronary deaths in the area of Augsburg, Germany. METHODS: Between 1995 and 2009, the MONICA/KORA myocardial infarction registry recorded 15,417 cases of MI and coronary deaths. Concentrations of PM<10μm (PM10), PM<2.5μm (PM2.5), particle number concentration (PNC) as indicator for ultrafine particles, and meteorological parameters were measured in the study region. Quasi-Poisson regression adjusting for time trend, temperature, season, and weekday was used to estimate immediate, delayed and cumulative effects of air pollutants on the occurrence of MI. The daily numbers of total MI, nonfatal and fatal events as well as incident and recurrent events were analysed. RESULTS: We observed a 1.3% risk increase (95%-confidence interval: [-0.9%; 3.6%]) for all events and a 4.4% [-0.4%; 9.4%] risk increase for recurrent events per 24.3μg/m(3) increase in same day PM10 concentrations. Nonfatal events indicated a risk increase of 3.1% [-0.1%; 6.5%] with previous day PM10. No association was seen for PM2.5 which was only available from 1999 on. PNC showed a risk increase of 6.0% [0.6%; 11.7%] for recurrent events per 5529 particles/cm(3) increase in 5-day average PNC. CONCLUSIONS: Our results suggested an association between short-term PM10 concentration and numbers of MI, especially for nonfatal and recurrent events. For ultrafine particles, risk increases were notably high for recurrent events. Thus, persons who already suffered a MI seemed to be more susceptible to air pollution.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Air Pollution ; Epidemiology ; Myocardial Infarction ; Particulate Matter ; Ultrafine Particles; Case-crossover Analysis; Time-series Data; Air-pollution; Hospital Admissions; Number Concentration; Coronary Deaths; Risk-factors; Health; Cities; Fine
ISSN (print) / ISBN 1438-4639
e-ISSN 1618-131X
Zeitschrift International Journal of Hygiene and Environmental Health
Quellenangaben Band: 218, Heft: 6, Seiten: 535-542 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Boston, Mass. ; London ; New York, NY ; Oxford ; Paris ; Philadelphia, Pa. ; San Diego, Calif. ; St. Louis, Mo. ; München
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)
Institute of Health Economics and Health Care Management (IGM)
Institute of Genetic Epidemiology (IGE)