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Stoy, C.* ; Sundaram, A.* ; Rios Garcia, M.* ; Wang, X.* ; Seibert, O.* ; Zota, A. ; Wendler, S.* ; Männle, D.* ; Hinz, U.* ; Sticht, C.* ; Muciek, M.* ; Gretz, N.* ; Rose, A.J.* ; Greiner, V.* ; Hofmann, T.G.* ; Bauer, A.* ; Hoheisel, J.* ; Berriel Diaz, M. ; Gaida, M.M.* ; Werner, J.* ; Schafmeier, T. ; Strobel, O.* ; Herzig, S.

Transcriptional co-factor Transducin Beta-Like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.

EMBO Mol. Med. 7, 1048-1062 (2015)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development of effective prognostic and therapeutic measures in PDAC. Here, we show that transcriptional co-factor Transducin beta-like (TBL) 1 was over-expressed in both human and murine PDAC. Inactivation of TBL1 in human and mouse pancreatic cancer cells reduced cellular proliferation and invasiveness, correlating with diminished glucose uptake, glycolytic flux, and oncogenic PI3 kinase signaling which in turn could rescue TBL1 deficiency-dependent phenotypes. TBL1 deficiency both prevented and reversed pancreatic tumor growth, mediated transcriptional PI3 kinase inhibition, and increased chemosensitivity of PDAC cells in vivo. As TBL1 mRNA levels were also found to correlate with PI3 kinase levels and overall survival in a cohort of human PDAC patients, TBL1 was identified as a checkpoint in the malignant behavior of pancreatic cancer and its expression may serve as a novel molecular target in the treatment of human PDAC.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Pi3 Kinase ; Tbl1 ; Gemcitabine ; Pancreatic Cancer ; Tumor Metabolism; Expression Profiles; Gene; Cells; 2-deoxy-d-glucose; Metabolism; Deafness; Tissue; Liver
ISSN (print) / ISBN 1757-4676
e-ISSN 1757-4684
Zeitschrift EMBO Molecular Medicine
Quellenangaben Band: 7, Heft: 8, Seiten: 1048-1062 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Chichester
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Institute of Diabetes and Regeneration Research (IDR)