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Huffman, J.E.* ; de Vries, P.S.* ; Morrison, A.C.* ; Sabater-Lleal, M.* ; Kacprowski, T.* ; Auer, P.L.* ; Brody, J.A.* ; Chasman, D.I.* ; Chen, M.H.* ; Guo, X.* ; Lin, L.-A.* ; Marioni, R.E.* ; Müller-Nurasyid, M. ; Yanek, L.R.* ; Pankratz, N.* ; Grove, M.L.* ; de Maat, M.P.M.* ; Cushman, M.* ; Wiggins, K.L.* ; Qi, L.* ; Sennblad, B.* ; Harris, S.E.* ; Polasek, O.* ; Riess, H.* ; Rivadeneira, F.* ; Rose, L.M.* ; Goel, A.* ; Taylor, K.D.* ; Teumer, A.* ; Uitterlinden, A.G.* ; Vaidya, D.* ; Yao, J.* ; Tang, W.* ; Levy, D.* ; Waldenberger, M. ; Becker, D.M.* ; Folsom, A.R.* ; Giulianini, F.* ; Greinacher, A.* ; Hofman, A.* ; Huang, C.C.* ; Kooperberg, C.* ; Silveira, A.* ; Starr, J.M.* ; Strauch, K. ; Strawbridge, R.J.* ; Wright, A.F.* ; McKnight, B.* ; Franco, O.H.* ; Zakai, N.* ; Mathias, R.A.* ; Psaty, B.M.* ; Ridker, P.M.* ; Tofler, G.H.* ; Völker, U.* ; Watkins, H.* ; Fornage, M.* ; Hamsten, A.* ; Deary, I.J.* ; Boerwinkle, E.* ; Koenig, W.* ; Rotter, J.I.* ; Hayward, C.* ; Dehghan, A.* ; Reiner, A.P.* ; O'Donnell, C.J.* ; Smith, N.L.*

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.

Blood 126, e19-e29 (2015)
Postprint DOI PMC
Open Access Green
Fibrinogen, coagulation factor VII (FVII), factor VIII (FVIII), and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities and additional variation may be explained by associations with rarer variants with larger effects. The aim of this study was to identify low-frequency (minor allele frequency [MAF] ≥0.01 and <0.05) and rare (MAF <0.01) variants that influence plasma concentrations of these 4 hemostatic factors by meta-analyzing exome chip data from up to 76,000 participants of 4 ancestries. We identified 12 novel associations of low-frequency (n=2) and rare (n=10) variants across the fibrinogen, FVII, FVIII, and vWF traits that were independent of previously identified associations. Novel loci were found within previously reported genes and had effect sizes much larger than and independent of previously identified common variants. In addition, associations at KCNT1, HID1, and KATNB1 identify new candidate genes related to hemostasis for follow-up replication and functional genomic analysis. Newly identified low-frequency and rare-variant associations accounted for modest amounts of trait variance and therefore are unlikely to increase predicted trait heritability but provide new information to understanding individual variation in hemostasis pathways.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 126, Heft: 11, Seiten: e19-e29 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)