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Kreymborg, K.G.* ; Haak, S. ; Murali, R.* ; Wei, J.* ; Waitz, R.* ; Gasteiger, G.* ; Savage, P.* ; van den Brink, M.R.* ; Allison, J.P.*

Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer.

Cancer Immunol. Res. 3, 849-854 (2015)
Postprint DOI PMC
Open Access Green
The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers its evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Regulatory T-cells; Ifn-gamma; B7 Family; Expression; Immunotherapy; Member; Mouse
ISSN (print) / ISBN 2326-6066
e-ISSN 2326-6074
Zeitschrift Cancer Immunology Research
Quellenangaben Band: 3, Heft: 8, Seiten: 849-854 Artikelnummer: , Supplement: ,
Verlag AACR
Verlagsort Philadelphia, Pa.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)