PuSH - Publikationsserver des Helmholtz Zentrums München: Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer.

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Kreymborg, K.G.* ; Haak, S. ; Murali, R.* ; Wei, J.* ; Waitz, R.* ; Gasteiger, G.* ; Savage, P.* ; van den Brink, M.R.* ; Allison, J.P.*

Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer.

Cancer Immunol. Res. 3, 849-854 (2015)

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The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers its evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.

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