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Ohnmacht, C. ; Park, J.H.* ; Cording, S.* ; Wing, J.B.* ; Atarashi, K.* ; Obata, Y.* ; Gaboriau-Routhiau, V.* ; Marques, R.* ; Dulauroy, S.* ; Fedoseeva, M. ; Busslinger, M.* ; Cerf-Bensussan, N.* ; Boneca, I.G.* ; Voehringer, D.* ; Hase, K.* ; Honda, K.* ; Sakaguchi, S.* ; Eberl, G.*

The microbiota regulates type 2 immunity through RORγt+ T cells.

Science 349, 989-993 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. While it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of pro-inflammatory T helper (Th) 17 cells and regulatory T cells (Tregs) in the intestine. Here, we report that microbiota-induced Tregs express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to Th17 cells. In the absence of RORγt(+) Tregs, Th2-driven defense against helminths is more efficient while Th2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of "type 3" RORγt(+) Tregs and Th17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ror-gamma-t; Innate Lymphoid-cells; Early-life; Proinflammatory Il-17(+); Commensal Bacteria; Oxazolone Colitis; Helper-cells; Differentiation; Inflammation; Susceptibility
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 349, Heft: 6251, Seiten: 989-993 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)