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Combs, S.E.

Individualized Radiotherapy (iRT) concepts for Locally Advanced Pancreatic Cancer (LAPC): Indications and prognostic factors.

Langenbecks Arch. Surg. 400, 749-756 (2015)
Verlagsversion DOI
Free journal
Background: Novel techniques in radiation oncology have significantly improved the therapeutic window in locally advanced pancreatic cancer LAPC. In about one third of the patients, chemoradiation can lead to secondary resectability, contributing to an increase in outcome. Dose-escalation approaches using stereotactic body radiotherapy (SBRT) or advanced treatments such as intensity-modulated radiotherapy (IMRT) can exploit the biological benefits of hypofractionation, or use “dose painting” approaches to target defined subvolumes. Prognostic subgroups of patients have been identified, based on molecular markers such as CA 19–9, nutritional factors, diabetes or immunological properties of tumor and normal tissue. Purpose: The aim of the present manuscript is to summarize data on downsizing for locally advanced pancreatic cancer (LAPC) and to elucidate the role of individualized radiotherapy (iRT). Conclusion: Future concepts focus on iRT based on prognostic factors leading to a true personalized treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Locally Advanced Pancreatic Cancer ; Neoadjuvant Chemoradiation ; Personalized Medicine ; Radiotherapy ; Stereotactic Body Radiotherapy (sbrt)
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1435-2443
e-ISSN 1435-2451
Zeitschrift Langenbeck's Archives of Surgery
Quellenangaben Band: 400, Heft: 7, Seiten: 749-756 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
DOI 10.1007/s00423-015-1309-8
WOS ID WOS:000364637600001
Scopus ID 84946493499
Scopus ID 84936805299
Erfassungsdatum 2015-07-23
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